Oncolytic Adenovirus (OAd)

Oncolytic adenoviruses are genetically engineered or naturally occurring adenoviruses designed to selectively infect, replicate within, and destroy cancer cells while sparing normal tissues. These viruses not only cause direct tumor cell lysis but also stimulate antitumor immune responses by releasing tumor-associated antigens and inducing local inflammation. Modern vectors often incorporate genetic modifications for improved selectivity, safety, delivery efficiency, or therapeutic payloads, making them a versatile platform for next-generation cancer immunotherapy strategies.

Other names

Replicating adenovirusEngineered adenovirusVirotherapy

Selective replication and lysis of cancer cells; induction of anti-tumor immune response