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Target intelligence / Profile preview
Vaccinia Virus (Oncolytic) (OVV)
- Target
- OVV
- Molecular classification
- Virus, Oncolytic Virus
01
Overview
Oncolytic vaccinia viruses (OVVs) are genetically engineered viruses designed to selectively infect, replicate within, and destroy tumor cells. OVVs induce oncolysis through multiple mechanisms, including direct cell lysis, disruption of tumor vasculature, and the activation of anti-tumor immune responses. Genetic modifications enhance safety and efficacy by restricting replication to tumor cells and expressing immunostimulatory transgenes. OVVs are being investigated in clinical trials as monotherapies and in combination with other cancer treatments.
- Other names
- Oncolytic Vaccinia VirusModified Vaccinia Ankara (MVA)PoxvirusKLS-3010SJ-series
02
Mechanism of action
Selective infection and replication in tumor cells, leading to direct oncolysis, disruption of tumor vasculature, and stimulation of anti-tumor immune responses.
03
Biological functions
InfectionOncolysisImmune stimulationTumor microenvironment modulation
04
Disease associations
CancerInfection (as a vector)
05
Safety considerations
Off-target infectionImmunogenicityCytokine stormNeurotoxicityHepatotoxicity
06
Interacting drugs
Immunomodulators
1 more in the full profile.
07
Biomarkers
Tumor typeExpression of RRM2Immune cell infiltrationViral shedding
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