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Target intelligence / Profile preview
Oncostatin M (OSM)
- Target
- OSM
- Molecular classification
- Cytokine, Interleukin 6 (IL-6) family, gp130 cytokine family
01
Overview
Oncostatin M (OSM) is a multifunctional, secreted cytokine that belongs to the IL-6 family. It signals through two main receptor complexes, Type I (gp130 + LIFR) and Type II (gp130 + OSMRβ), activating several intracellular signaling pathways including JAK/STAT, RAS/MAPK, JNK/p38 MAPK, and PI3K/AKT. OSM exhibits pleiotropic effects across multiple physiological systems, including regulating cell proliferation, differentiation, apoptosis, modulating immune responses, and influencing hematopoiesis. Elevated levels or dysregulation of OSM are implicated in several diseases, including rheumatoid arthritis, pulmonary inflammation/fibrosis, and cardiovascular diseases. Therapeutic strategies targeting the OSM signaling axis, such as monoclonal antibodies and small molecule inhibitors, are under investigation.
- Other names
- OSM
02
Mechanism of action
Modulation of pathological inflammation while minimizing side effects via antagonism of OSM or its receptors, or downstream signaling pathways.
03
Biological functions
Cell proliferationCell differentiationApoptosisImmune responseHematopoiesisLiver development/regenerationBone formationBone resorptionCartilage degradationRegulation of inflammation
04
Disease associations
Rheumatoid arthritisPulmonary inflammationPulmonary fibrosisCardiovascular diseasesHeart fibrosisCancer
05
Safety considerations
Potential for pro-tumorigenic or anti-tumorigenic effects depending on contextSide effects associated with broad immunosuppression
06
Interacting drugs
Monoclonal antibodies against OSM or its receptors
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