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Interleukin 31 Receptor Pathway via OSMRβ Inhibition

Molecular classification: Receptor, Cytokine receptor, Heterodimeric receptor

Overview

The interleukin 31 receptor is a heterodimeric complex composed of IL-31 receptor A (IL-31RA) and oncostatin M receptor beta (OSMRβ). IL-31 binding activates JAK/STAT, PI3K/AKT, and MAPK signaling pathways, leading to diverse biological functions including immune regulation, tissue remodeling, and pruritus mediation. Inhibiting the OSMRβ subunit disrupts the receptor complex and prevents downstream pro-inflammatory and neurogenic effects, making it a therapeutic target for chronic pruritic conditions.

Other names: IL-31 receptorIL31RA/OSMRβ complexOncostatin M Receptor beta

Mechanism of action

Inhibition of IL-31 receptor signaling by blocking OSMRβ subunit; prevents activation of JAK/STAT, PI3K/AKT, and MAPK pathways

Biological functions

Immune regulationTissue remodelingPruritus mediationHematopoiesisSignal transduction

Disease associations

Atopic dermatitisPruritusAirway hypersensitivityInflammatory bowel disease

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