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Target intelligence / Profile preview
Oncostatin M Receptor Beta Subunit (OSMRβ)
- Target
- OSMRβ
- Molecular classification
- Type I cytokine receptor
01
Overview
Oncostatin M Receptor Beta Subunit (OSMRβ) is a member of the type I cytokine receptor family. It forms heterodimeric complexes with gp130 (IL6ST) to form the type II Oncostatin M Receptor that binds oncostatin M (OSM) and with interleukin 31 receptor A (IL31RA) to form the Interleukin 31 Receptor that binds interleukin 31 (IL-31). These complexes activate JAK/STAT, MAPK, and PI3K/Akt pathways, leading to diverse cellular responses. OSMR is widely expressed and its dysregulation is associated with diseases like familial primary localized cutaneous amyloidosis. It is being explored as a therapeutic target for cancer and inflammatory diseases.
- Other names
- OSMROSMRBPLCA1IL-31R-betaIL-31RBOncostatin M receptor beta subunit
02
Mechanism of action
JAK/STAT pathway activation; MAPK cascade activation; PI3K/Akt pathway activation
03
Biological functions
Signal transductionReceptor bindingCell proliferationCell differentiationApoptosisInflammationTissue remodelingCell motility regulationAngiogenesisInnate immunity modulation
04
Disease associations
Familial primary localized cutaneous amyloidosisPrimary cutaneous amyloidosisInflammatory diseasesCancerPruritus
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