Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Oncotrophoblast Glycoprotein 5T4 (TPBG)
- Target
- TPBG
- Molecular classification
- Type I transmembrane glycoprotein, Oncofetal antigen
01
Overview
Oncotrophoblast glycoprotein 5T4 (TPBG) is a type I transmembrane glycoprotein involved in cell adhesion, migration, and Wnt signaling. It is highly expressed in various carcinomas but has limited expression in normal adult tissues, making it an attractive target for cancer therapy. It interacts with GIPC1 and plays a role in EMT and chemotaxis. Experimental therapies include monoclonal antibodies, antibody-drug conjugates, and cancer vaccines.
- Other names
- Trophoblast glycoprotein5T4Wnt-Activated Inhibitory Factor 1WAIF1M6P1
02
Mechanism of action
Monoclonal antibodies (e.g., mAb5T4) delivering response modifiers directly to tumors; Cancer vaccines (e.g., TroVax)
03
Biological functions
Cell adhesion regulationCell migration regulationCytoskeletal organizationInhibition of canonical Wnt/β-catenin signalingRegulation of CXCL12/CXCR4 chemotaxisEpithelial-mesenchymal transition (EMT)
04
Disease associations
Cancer
05
Safety considerations
Potential off-target effects due to expression in placental syncytiotrophoblasts.
06
Biomarkers
TPBG expression in tumors
Beyond the preview
Go deeper on Oncotrophoblast Glycoprotein 5T4 (TPBG).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Oncotrophoblast Glycoprotein 5T4 (TPBG).