One-carbon metabolism enzyme

One-carbon metabolism enzymes refer to a group of enzymes that catalyze the transfer and utilization of single-carbon units in cellular metabolism, primarily through the folate and methionine cycles[3][6][1]. These enzymes are essential for nucleotide and amino acid synthesis, methylation reactions affecting DNA and proteins, and maintaining redox balance[1][2][5][6]. Prominent examples include serine hydroxymethyltransferase (SHMT), methylenetetrahydrofolate reductase (MTHFR), methionine adenosyltransferase (MAT), and others involved in the folate cycle and related pathways[3][5][6]. Because of their role in supporting cell growth and proliferation, these enzymes are therapeutic targets in cancer and other diseases, with several anticancer agents (e.g., methotrexate, 5-fluorouracil) specifically inhibiting key one-carbon metabolism enzymes[1][2][5][6][3]. Given that the submitted target name ("One-carbon metabolism enzymes") is a group rather than a single molecular entity, it is not fully specific; thus, is_incorrect: true[1][5][3]. If you require detailed structured information on a **specific one-carbon metabolism enzyme** (e.g., serine hydroxymethyltransferase, methylenetetrahydrofolate reductase), please specify which enzyme, and a canonical entry can be provided.

Other names

One-carbon metabolic enzymeFolate pathway enzymeMethionine cycle enzyme1C metabolism enzyme

Inhibition of folate-dependent enzymes, inhibition of thymidylate synthase, and inhibition of methionine synthesis.