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Oocyte-expressed protein homolog (OOEP)
- Target
- OOEP
- Molecular classification
- Other, component of the subcortical maternal complex, RNA-binding protein
01
Overview
Oocyte-expressed protein homolog (OOEP) is a cytoplasmic and nuclear protein involved in oocyte maturation and early embryonic development. It is a key component of the subcortical maternal complex (SCMC), which is essential for the first divisions after fertilization. OOEP promotes RNA binding, regulates actin cytoskeleton dynamics critical for mitotic spindle formation and placement, and actively supports the homologous recombination-mediated DNA double-strand break repair pathway in oocytes. It is vital for oocyte survival, meiotic resumption, and symmetric zygotic division. Variants in OOEP are associated with developmental disorders including Temple syndrome and gestational trophoblastic neoplasm.
- Other names
- C6orf156KHDC2OEP19hOEP19Em:AC019205.2Oocyte- and embryo-specific protein 19FLOPEDHOEP19KH homology domain-containing protein 2Oocyte and embryo protein 19Oocyte expressed protein homolog (dog)Oocyte- and embryo-specific protein 19 (dog)OOEP
02
Biological functions
RNA bindingStructural constituent of cytoplasmic latticePositive regulation of double-strand break repair via homologous recombinationPositive regulation of meiotic nuclear divisionCytoskeleton organizationActin dynamics regulationEssential for early embryonic development and zygote division
03
Disease associations
Temple syndromeGestational trophoblastic neoplasmOther developmental disorders may be implicated based on general functions, but no strong association to common diseases like cancer or infection is reported
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