Opa-interacting protein 5 antisense RNA 1 (OIP5-AS1) (OIP5-AS1)

Opa-interacting protein 5 antisense RNA 1 (OIP5-AS1), also known as Cyrano, is a highly conserved long non-coding RNA (lncRNA) that plays a pivotal role in various biological processes and disease states [NIH, 2022; GeneCards]. It primarily functions as a competing endogenous RNA (ceRNA) or molecular sponge, sequestering microRNAs such as miR-137, miR-143-3p, and miR-29b-3p to regulate the expression of downstream target genes [NIH, 2020; Frontiers, 2025]. These interactions influence critical cellular activities, including cell proliferation, apoptosis, autophagy, and mitochondrial dynamics [NIH, 2022; ResearchGate, 2020]. In oncology, OIP5-AS1 is frequently upregulated and acts as an oncogene in several cancers, such as lung, gastric, and cervical cancer, where it promotes tumor progression and metastasis [NIH, 2018; NIH, 2026]. It also contributes to chemoresistance against drugs like cisplatin and temozolomide by modulating survival pathways [NIH, 2021; NIH, 2022]. In contrast, OIP5-AS1 exhibits neuroprotective properties in neurodegenerative diseases like Parkinson's by promoting mitochondrial health and reducing protein toxicity [NIH, 2021; ResearchGate, 2020]. Beyond cancer and neurodegeneration, it is involved in inflammatory conditions like rheumatoid arthritis and intervertebral disc degeneration [NIH, 2022; MDPI, 2021]. Given its widespread dysregulation and functional importance, OIP5-AS1 is being explored as a diagnostic biomarker and a potential therapeutic target for antisense-based strategies [NIH, 2022; MDPI, 2021].

Other names

CyranoOip5os11700020I14RikLinc-OIP5OIP5 antisense RNA 1 (non-protein coding)

Antisense-mediated knockdown, siRNA-mediated silencing, and competitive inhibition of miRNA sponging.