Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Opioid Growth Factor Receptor (OGFr)
- Target
- OGFr
- Molecular classification
- Receptor
01
Overview
The opioid growth factor receptor (OGFr) is a unique receptor that specifically binds the endogenous opioid peptide [Met(5)]-enkephalin, also known as opioid growth factor (OGF). It is not structurally related to classical opioid receptors and mediates growth-inhibitory effects through direct modulation of gene expression after translocation into the nucleus. It plays critical roles in embryonic development, wound healing, cellular renewal, angiogenesis, cancer biology, and tissue repair processes. Modulating this axis holds promise for cancer management and autoimmune disorders.
- Other names
- OGFr
02
Mechanism of action
Increases synthesis of cyclin-dependent kinase inhibitors p12 and p16, leading to inhibition of retinoblastoma protein phosphorylation, causing cell cycle arrest at G1 phase.
03
Biological functions
Cell proliferationTissue organizationEmbryonic developmentWound healingCellular renewalAngiogenesis
04
Disease associations
CancerAutoimmune disorders
05
Safety considerations
Blockade or dysregulation can lead to altered rates of cellular proliferation
06
Interacting drugs
Imiquimod
2 more in the full profile.
07
Biomarkers
Potential biomarker in oncology research
Beyond the preview
Go deeper on Opioid Growth Factor Receptor (OGFr).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Opioid Growth Factor Receptor (OGFr).