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Opioid Receptor Delta-Type (DOR)
- Target
- DOR
- Molecular classification
- GPCR, G protein-coupled receptor, 7-transmembrane receptor, Class A Rhodopsin-like receptor
01
Overview
The delta opioid receptor (DOR), also known as δ-opioid receptor or DOP, is a member of the opioid receptor family and a seven-transmembrane G protein-coupled receptor that primarily couples to inhibitory G proteins (Gi/G0). It mediates its effects through modulation of intracellular signaling pathways and is heavily expressed in the basal ganglia and neocortical regions of the brain. Activation reduces pain (especially chronic pain) and improves negative emotional states. DOR is considered a promising target for chronic pain management and the treatment of mood disorders.
- Other names
- δ-opioid receptorDOPOPRD1
02
Mechanism of action
Activation reduces neuronal excitability, inhibits adenylyl cyclase, modulates ion channels, and undergoes desensitization/internalization upon prolonged stimulation.
03
Biological functions
AnalgesiaMood regulationSignal transductionInhibition of adenylyl cyclaseModulation of ion channelsRegulation of drug reward pathwaysInhibitory controlLearning processesNeuroprotectionLocomotor activity
04
Disease associations
Chronic painMood disordersDepressionAnxiety
05
Safety considerations
Potential for seizures at high agonist dosesRespiratory depression (lower risk compared to mu-opioid agonists, but still possible)
06
Interacting drugs
Enkephalins
2 more in the full profile.
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