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Target intelligence / Profile preview
Opioid Receptor Kappa (KOR)
- Target
- KOR
- Molecular classification
- G protein-coupled receptor, GPCR, Receptor
01
Overview
The kappa opioid receptor (KOR) is a G protein-coupled receptor that binds to dynorphins and modulates several physiological processes including analgesia, stress response, mood regulation, reward processing, and inflammation control. Activation can induce diuresis and cause dysphoria and aversion. Unlike mu-opioid receptors, it does not cause respiratory depression, making it a potentially safer target for pain management. Widespread clinical use is limited by adverse effects such as dysphoria/sedation/aversion.
- Other names
- Kappa opioid receptorκ-opioid receptorKOR-1Kappa receptorOP 2KOPKOPr
02
Mechanism of action
Agonist binding leads to Gi/G0 protein coupling, inhibition of adenylyl cyclase, and reduced neuronal excitability.
03
Biological functions
AnalgesiaPain modulationStress responseMood regulationReward processingAnti-reward effectsDiuresisInflammation controlSignal transduction
04
Disease associations
Pain disordersPruritusAddictionDepressionInflammatory diseasesMultiple sclerosisAlzheimer’s diseaseGastrointestinal diseasesCancerIschemic conditions
05
Safety considerations
DysphoriaSedationAversionSex-specific differences in distribution/function
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