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Target intelligence / Profile preview
Opioid Receptor Kappa-Type (KOR)
- Target
- KOR
- Molecular classification
- G protein-coupled receptor, GPCR, Receptor
01
Overview
The kappa opioid receptor (KOR) is a G protein-coupled receptor that primarily binds dynorphins. It mediates various physiological processes including analgesia (without respiratory depression), diuresis, and dysphoria. Due to its role in pain modulation and reward pathways, it is a target for novel analgesics and treatments for addiction and mood disorders.
- Other names
- κ-opioid receptorOP2KOPrKappa receptor
02
Mechanism of action
Gi/o protein coupling that suppresses adenylyl cyclase activity, leading to reduced cAMP levels within cells.
03
Biological functions
AnalgesiaPain modulationDiuresisMood regulationModulation of consciousnessMotor controlRegulation of dopamine secretionBehavioral responses to drugsImmune response modulationEating behavior regulationMaternal behavior influenceSensory perceptionTemperature stimuli processingSignal transduction
04
Disease associations
PainAddictionDepressionMood disorders
05
Safety considerations
DysphoriaAnti-reward effects
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