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Target intelligence / Profile preview
Opioid Receptor Mu (MOR)
- Target
- MOR
- Molecular classification
- G protein-coupled receptor (GPCR), Receptor
01
Overview
The mu opioid receptor (MOR), encoded by the OPRM1 gene, is a G protein-coupled receptor and the primary target for opioid analgesics and endogenous opioid peptides. It mediates analgesia, reward, respiratory depression, sedation, and gastrointestinal effects. Genetic variations in OPRM1 influence individual opioid sensitivity and addiction risk. MORs form dimers with other GPCRs, modulating their pharmacology. Biased agonism is being explored to separate analgesic effects from adverse side effects.
- Other names
- Mu receptorMOPOP3MOPropioid receptor mu 1
02
Mechanism of action
Agonist binding to the mu opioid receptor leads to Gi/o protein activation, inhibition of adenylyl cyclase, decreased cAMP production, and neuronal hyperpolarization via potassium channel activation and/or calcium channel inactivation.
03
Biological functions
Analgesia/pain reliefReward sensation/euphoriaSedationRegulation of respirationRegulation of gastrointestinal motilitySignal transduction
04
Disease associations
Pain (acute and chronic)AddictionRespiratory disorders
05
Safety considerations
Respiratory depressionAddictionToleranceDependenceConstipationOverdose
06
Interacting drugs
Morphine
8 more in the full profile.
07
Biomarkers
OPRM1 gene polymorphisms (SNPs) associated with opioid sensitivity and addiction risk
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