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Opioidergic System
- Molecular classification
- G protein-coupled receptor, Receptor, Ligand-receptor system
01
Overview
The opioidergic system is a network of opioid receptors (Mu, Delta, Kappa, and NOP/ORL1), their endogenous ligands (β-Endorphin, Enkephalins, Dynorphins), and exogenous agents (opioid drugs) that modulate these receptors. This system plays a central role in pain modulation, reward, mood regulation, addiction, and various physiological processes. Activation generally leads to reduced neuronal excitability via hyperpolarization or inhibition of neurotransmitter release.
- Other names
- Opioid systemEndogenous opioid system
02
Mechanism of action
Activation or inhibition of opioid receptors (Mu, Delta, Kappa, NOP) leading to downstream signaling effects such as inhibition of adenylyl cyclase activity, changes in ion channel conductance, and modulation of neurotransmitter release.
03
Biological functions
Pain modulationRewardMood regulationGastrointestinal motilityRespiration controlImmune response
04
Disease associations
PainAddictionDepressionAnxietyGastrointestinal disorders
05
Safety considerations
ToleranceDependenceAddictionRespiratory depressionEuphoria/DysphoriaHallucinations
06
Interacting drugs
Morphine
4 more in the full profile.
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