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Optic Nerve Cell Protection
- Molecular classification
- Other
01
Overview
Optic nerve cell protection encompasses a set of molecular targets—including anti-apoptotic pathways (CREB/BCL‑2), trophic factor signaling (BDNF), stress response elements (HSF‑regulated OSK)—that together aim to preserve or restore retinal ganglion cells after insult. These targets are under active investigation as therapeutic entry points for preventing irreversible vision loss from various forms of optic neuropathy.
02
Mechanism of action
Various, including: activation of CREB/BCL-2 pathway, neurotrophic factor support, modulation of apoptosis, induction of pluripotency factors
03
Biological functions
NeuroprotectionCell survivalAxon regenerationSynaptic reconnectionAnti-apoptosisTrophic support
04
Disease associations
GlaucomaIschemic optic neuropathyLeber’s hereditary optic neuropathyOptic neuropathy
05
Safety considerations
Challenges translating preclinical success into human efficacyPotential off-target effects of gene therapyDelivery challenges for growth factors/neurotrophinsAchieving functional integration of transplanted stem/progenitor cells
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