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Target intelligence / Profile preview
OR2A1 antisense RNA 1 (OR2A1-AS1)
- Target
- OR2A1-AS1
- Molecular classification
- Long non-coding RNA (lncRNA)
01
Overview
OR2A1 antisense RNA 1 (OR2A1-AS1) is a long non-coding RNA (lncRNA) gene located on chromosome 11, thought to regulate the expression of the OR2A1 olfactory receptor gene[1][2][5]. While the precise molecular function of OR2A1-AS1 remains unclear, some evidence indicates it may serve as a regulatory RNA influencing gene expression patterns. In oncology, decreased OR2A1-AS1 expression has been associated with poorer prognosis in diffuse large B-cell lymphoma (DLBCL), particularly within the germinal center B-cell-like subtype, making it a candidate prognostic biomarker rather than a direct therapeutic target[3][4][6]. No drugs or active efforts to target this lncRNA therapeutically are currently known.
02
Mechanism of action
Not applicable; no drugs directly target this lncRNA as of current data
03
Biological functions
Regulation of gene expressionPossible regulatory effect on olfactory receptor gene OR2A1Prognostic biomarker in diffuse large B-cell lymphoma (DLBCL)
04
Disease associations
Cancer (notably diffuse large B-cell lymphoma)Other (role in olfactory gene regulation, general function is poorly defined)
05
Safety considerations
None reported. There are no therapies directly targeting this lncRNA, so safety concerns or therapeutic challenges are undefined.
06
Biomarkers
Low expression is a prognostic biomarker for shorter overall survival and progression-free survival in DLBCL, especially in the germinal center B-cell-like subtype
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