Target intelligence / Profile preview

Oral Bacterial Biofilm (N/A)

Target
N/A
Molecular classification
Polymicrobial Community, Extracellular Matrix, Bacterial Aggregate
01

Overview

Oral bacterial biofilm is a highly structured community of microorganisms, primarily bacteria, encased in a self-produced extracellular matrix. It forms on surfaces in the mouth, most notably teeth (dental plaque), and plays a crucial role in both oral health and the development of diseases like dental caries and periodontal disease. Targeting the biofilm involves disrupting its structure, inhibiting its formation, or eradicating the resident microbes, while minimizing disruption to the beneficial oral microbiota.

Other names
Dental PlaqueOral BiofilmMicrobial Biofilm (oral)
02

Mechanism of action

Disruption of biofilm structure, inhibition of EPS synthesis, blocking adhesion, antimicrobial activity, EPS degradation

03

Biological functions

Microbial ColonizationNutrient RetentionQuorum SensingProtection from AntimicrobialsImmune EvasionHorizontal Gene TransferMetabolic Cooperation
04

Disease associations

Dental CariesPeriodontal DiseasesGingivitisPeriodontitisOral Infections
05

Safety considerations

Development of antibiotic resistanceDisruption of commensal floraHost immune response to biofilm componentsIneffective penetration of antimicrobials into mature biofilmsBiofilm regrowth
06

Interacting drugs

Antibiotics

6 more in the full profile.

07

Biomarkers

Microbial composition (specific pathogens)EPS matrix componentsInflammatory markers (e.g., cytokines)

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