Oral cavity bacterium

Oral cavity bacteria comprise a highly complex, site-specific community of microorganisms inhabiting the human mouth, with over 700 described species spanning at least 12 bacterial phyla, such as Firmicutes, Proteobacteria, Actinobacteria, Bacteroidetes, and Fusobacteria[1][3][5]. These bacteria exist in symbiotic equilibrium, contributing to oral and general health, but shifts in composition (dysbiosis) can trigger oral and systemic diseases, including dental caries, periodontitis, and links to cardiovascular and metabolic disorders. Intervention strategies are shifting toward selective targeting of pathogenic bacteria or restoration of healthy communities through probiotics or microbiota transplantation, rather than broad-spectrum microbial eradication[2][4][6].

Other names

oral microbiotaoral microbiomeoral florahuman oral bacterial community

Broad-spectrum antimicrobial action (disrupting or killing diverse oral bacteria) Targeted eradication of dysbiotic/pathogenic bacteria (e.g., inhibition of glucan synthesis in *S. mutans*) Probiotic colonization and competitive exclusion of pathogens Biofilm modulation Immunomodulation