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Oral microbiota composition modulation
- Molecular classification
- Other (not a molecule, receptor, or protein; refers to ecological communities and their management)
01
Overview
Oral microbiota composition modulation describes any intervention or process that deliberately alters the types and relative abundances of microorganisms in the oral cavity, with the aim to restore or promote a balanced microbial ecosystem (eubiosis) and prevent or treat oral and related systemic diseases. Techniques include use of probiotics, antiseptics, antibiotics, dietary modification, and improved oral hygiene. It is a rapidly developing therapeutic strategy, but is not a molecular target—rather, it is a conceptual goal in oral health management
- Other names
- oral microbiome modulationmicrobial modulation (oral cavity)oral microbiota regulationoral microbiota manipulation
02
Mechanism of action
Promotion of beneficial microbes; Suppression/elimination of pathogenic species; Restoration of ecological balance (eubiosis); Disruption of biofilms; Immune system modulation
03
Biological functions
Maintenance of oral healthPrevention and treatment of oral diseaseRegulation of immune responseSupport of systemic health
04
Disease associations
Dental cariesPeriodontal diseaseOral infectionSystemic diseases linked to oral dysbiosis (e.g., diabetes, cardiovascular disease, cancer)
05
Safety considerations
Non-specific targeting may disrupt beneficial commensalsAntibiotic resistanceUnknown long-term effects of extensive microbiota manipulation
06
Interacting drugs
Probiotics
3 more in the full profile.
07
Biomarkers
Microbial diversity indicesRelative abundance of specific taxa (e.g., *Streptococcus mutans*, *Porphyromonas gingivalis*)Signs of oral dysbiosis, e.g., plaque composition
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