Oral mucosal surface and salivary pellicle

The oral mucosal surface and salivary pellicle represent a complex biological interface comprising mammalian oral epithelial cell membranes and a protective layer of adsorbed salivary proteins (StatPearls, NBK544288). This environment serves as a critical barrier against mechanical stress, chemical insults, and microbial invasion, while also facilitating lubrication and sensory functions (PubMed, 28838614). Key molecular components include secreted and membrane-bound mucins, such as MUC5B and MUC7, which provide viscoelastic properties and mediate cell signaling (UniProt, Q9HC84). In therapeutic contexts, this surface is not a single molecular target but a site for mucoadhesive drug delivery systems designed to increase the residence time of topical treatments for conditions like oral mucositis or candidiasis (PubMed, 31221731). Furthermore, various pathogens utilize specific receptors on these membranes, such as ACE2 or integrins, to initiate infection (PubMed, 32358202).

Other names

Oral mucosaBuccal mucosaSalivary mucosal barrierOral epithelial barrierAcquired salivary pellicleMucosal pellicle

Mucoadhesion through non-covalent interactions (hydrogen bonding, van der Waals forces, and electrostatic interactions) with mucosal glycoproteins and physical barrier enhancement.