Orbital inflammatory cells

Inflammatory cells in orbital tissue refer to a collection of immune cells that infiltrate the orbital fat compartment and surrounding structures during inflammatory orbital diseases. These cells play an active role in the pathogenesis of various orbital inflammatory conditions. They include various immune cell types such as macrophages, T cells, B cells, and other inflammatory cells that diffusely infiltrate the orbital fat compartment. They are responsible for producing and releasing various pro-inflammatory mediators including pro-inflammatory cytokines (IL-6, TNF-α, IL-1β, IL-17A, IL-2, IL-8, IL-10, IL-12, and gamma interferon), fibrogenic growth factors, oxygen-free radicals, and glycosaminoglycans. These mediators act on orbital fat and surrounding tissues, stimulating various pathological processes including adipogenesis, fibroblast proliferation, and expression of immunomodulatory molecules.

Other names

Inflammatory cells in orbital tissueImmune cells in orbital tissue

Drugs targeting these cells or their mediators work by suppressing the immune response and inflammation, thereby reducing cellular infiltration and the production of pro-inflammatory mediators.