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ORC ubiquitin ligase 1 (OBI1)
- Target
- OBI1
- Molecular classification
- Enzyme, E3 ubiquitin ligase
01
Overview
ORC ubiquitin ligase 1 (OBI1) is an essential E3 ubiquitin ligase in humans, involved in selecting origins of DNA replication and activating them via multi-mono-ubiquitination of ORC3 and ORC5 subunits during S phase. It is a chromatin-associated factor whose activity ensures proper DNA replication origin firing, critical for genome stability and normal cell cycle progression. Defects or silencing of OBI1 result in impaired replication origin firing, reduced replisome formation, and potentially altered cell proliferation; it is implicated in cancer biology, and its molecular activity may represent a potential therapeutic target for diseases involving dysregulated DNA replication.
- Other names
- OBI1RNF219C13orf7
02
Mechanism of action
Catalyzes the multi-mono-ubiquitination of chromatin-bound ORC3 and ORC5 to trigger replication origin firing during S phase. Acts as a replication origin selector.
03
Biological functions
Regulation of DNA replication origin activationChromatin bindingUbiquitin-protein transferase activityProtein autoubiquitinationProtein monoubiquitination
04
Disease associations
Cancer (notably bladder small cell carcinoma)Potential links to replication stress and cell cycle disorders
05
Safety considerations
Notable therapeutic challenges may include effects on cell proliferation and genomic stability if targeted, given its essential role in DNA replication initiation
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