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Orexin Neuron (N/A)
- Target
- N/A
- Molecular classification
- Neuron, Neuroendocrine cell
01
Overview
Orexin neurons are specialized neurons located in the lateral hypothalamus that produce and release orexin neuropeptides (also known as hypocretins). These neurons play a central role in regulating arousal, wakefulness, feeding behavior, energy homeostasis, and autonomic functions. Activation of these neurons promotes sustained arousal/wakefulness. Orexin neurons project widely throughout the brain, including to monoaminergic nuclei such as the locus coeruleus, ventral tegmental area, and tuberomammillary nucleus.
- Other names
- Hypocretin NeuronOrexinergic NeuronHCRT Neuron
02
Mechanism of action
N/A (Neurons are not directly targeted by drugs; receptors on the neurons are)
03
Biological functions
Wakefulness regulationArousalFeeding behaviorEnergy homeostasisAutonomic functionRegulation of sleep-wake cycle
04
Disease associations
NarcolepsyObesityMetabolic syndromeSleep disorders
05
Interacting drugs
Clozapine-N-Oxide
1 more in the full profile.
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