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Target intelligence / Profile preview
Orexin Receptor 1 (OX1R)
- Target
- OX1R
- Molecular classification
- G protein-coupled receptor
01
Overview
Orexin receptor 1 (OX1R), also known as hypocretin receptor 1, is a G-protein coupled receptor (GPCR) primarily expressed in projections from the lateral hypothalamus. It plays a key role in regulating feeding behavior, arousal, wakefulness, reward processing, and locomotion. OX1R binds orexin-A with high affinity, activating phospholipase C pathways and increasing intracellular calcium.
- Other names
- HCRTR1Hypocretin receptor 1ORXR1OXR1
02
Mechanism of action
Gq protein activation leading to phospholipase C activation and increased intracellular calcium levels. Possible Gi protein coupling affecting cAMP levels.
03
Biological functions
Signal transductionRegulation of feeding behaviorRegulation of arousalRegulation of wakefulnessReward processingRegulation of locomotionEnergy metabolismStress responseSympathetic tone regulation
04
Disease associations
Sleep disordersAddictionMetabolic disorders
05
Safety considerations
Potential for drug interactionsDaytime somnolence
06
Interacting drugs
RTIOX-276
9 more in the full profile.
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