Target intelligence / Profile preview

Organic Anion Transporter 3 (OAT3)

Target: OAT3
Molecular classification: Transporter, Solute Carrier Family 22

Overview

Organic anion transporter 3 (OAT3), encoded by the SLC22A8 gene, is a multispecific transporter protein primarily expressed in the basolateral membrane of renal proximal tubule cells. It mediates the uptake and secretion of a wide variety of organic anions, including drugs and metabolites, playing a critical role in renal elimination. Genetic variations can affect drug disposition and toxicity.

Other names: SLC22A8

Mechanism of action

Organic anion/dicarboxylate exchanger

Biological functions

Drug transportMetabolite transportOrganic anion transportDicarboxylate exchange

Safety considerations

Drug-drug interactions due to altered drug clearancePharmacogenomic variability leading to altered drug responsePotential for increased toxicity due to altered drug disposition

Interacting drugs

Penicillin G

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