Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Organic Anion Transporter 4 (OAT4)
- Target
- OAT4
- Molecular classification
- Transporter, Membrane Transport Protein, Organic Anion Transporter
01
Overview
Organic Anion Transporter 4 (OAT4), encoded by the SLC22A11 gene, is a member of the organic anion transporter family. Primarily located on the apical membrane of renal proximal tubule cells, it functions as an organic anion/dicarboxylate exchanger, mediating the transport of various endogenous and exogenous organic anions, including steroid sulfates and clinically important drugs. OAT4 plays a crucial role in renal drug disposition and the handling of uremic toxins, influencing drug efficacy, toxicity, and kidney disease pathophysiology. Its activity is modulated by interactions with PDZ domain-containing scaffold proteins, affecting its surface expression and transport capacity.
- Other names
- SLC22A11
02
Mechanism of action
Organic anion/dicarboxylate exchange. Indirectly coupled to sodium gradients via dicarboxylate exchange.
03
Biological functions
Drug transportOrganic anion transportReabsorptionSecretionDicarboxylate exchange
04
Disease associations
Kidney diseaseDrug toxicityUremic toxicity
05
Safety considerations
Drug-drug interactionsPotential for altered drug efficacy due to transport modulationNephrotoxicity
06
Interacting drugs
Anti-HIV agents
6 more in the full profile.
Beyond the preview
Go deeper on Organic Anion Transporter 4 (OAT4).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Organic Anion Transporter 4 (OAT4).