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Target intelligence / Profile preview
Organic Anion Transporting Polypeptide (OATP)
- Target
- OATP
- Molecular classification
- Transporter, Membrane Transport Protein, Solute Carrier (SLC)
01
Overview
Organic anion transporting polypeptides (OATPs) are a superfamily of membrane-bound transport proteins that mediate the sodium-independent uptake of a wide variety of endogenous and exogenous organic anions, as well as some neutral and cationic compounds, into cells. They are classified within the solute carrier (SLC) transporter family and play critical roles in hepatic drug clearance, intestinal absorption, and blood-brain barrier transport. Genetic polymorphisms and drug interactions involving OATPs can significantly impact drug efficacy and toxicity.
- Other names
- SLCO familySolute carrier organic anion transporter familySLC21 family
02
Mechanism of action
Na+-independent transport of organic anions, neutral, and cationic compounds across cell membranes
03
Biological functions
Drug transportBile acid transportBilirubin transportSteroid hormone transportThyroid hormone transportProstaglandin transportPeptide transportHepatic drug clearanceIntestinal absorptionBlood-brain barrier transport
04
Disease associations
Drug-drug interactionsPharmacokinetics variabilityLiver diseaseCancer (drug resistance)Neurological disorders (blood-brain barrier transport)
05
Safety considerations
Drug-drug interactions (altered pharmacokinetics)Genetic polymorphisms (variable drug response)Off-target effects
06
Interacting drugs
Statins
7 more in the full profile.
07
Biomarkers
Bromosulphopthalein (liver function)SLCO1B1 polymorphisms (drug response)
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