Organic anion transporting polypeptide 2B1, Organic anion transporting polypeptide 1B1, Organic anion transporting polypeptide 1B3 (OATP2B1 (for Solute carrier organic anion transporter family member 2B1), OATP1B1 (for Solute carrier organic anion transporter family member 1B1), OATP1B3 (for Solute carrier organic anion transporter family member 1B3))

Organic anion transporting polypeptide 2B1 (OATP2B1, encoded by SLCO2B1), OATP1B1 (SLCO1B1), and OATP1B3 (SLCO1B3) are members of the solute carrier (SLC) superfamily of membrane transporters that facilitate the uptake of a wide range of endogenous and exogenous organic anions, including drugs, toxins, bile acids, and hormones, across the plasma membrane[1][2][3][4][5]. OATP2B1 is widely expressed, including in the intestine, liver, placenta, and various endothelial tissues, and plays a key role in drug absorption, disposition, and hormone regulation[1][3]. OATP1B1 and OATP1B3 are primarily liver-specific, located on the basolateral (sinusoidal) membrane of hepatocytes, serving as gatekeepers for hepatic drug uptake and subsequent metabolism or excretion[4][6][7]. These transporters exhibit broad substrate overlap but can differ in specificity and tissue distribution. They are clinically important due to their involvement in drug–drug interactions, genetic polymorphism-related variability in drug response, and as determinants of drug-induced toxicities, particularly with statins and chemotherapeutics[1][2][3][7]. Each transporter (OATP2B1, OATP1B1, OATP1B3) should be recorded as an individual target for structured databases. "OATP2B1/1B1/1B3 transporters" is an aggregate term and should not be used as a canonical entry.

Other names

OATP-BOATPBSLC21A9SLCO2B1SLC21A6SLCO1B1SLC21A8SLCO1B3

Substrate uptake via Na⁺-independent, facilitated diffusion Drug–drug interaction (inhibition or competition can alter drug absorption and clearance)