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Organic Cation Transporter 2 (OCT2)
- Target
- OCT2
- Molecular classification
- Solute Carrier Family 22, Organic Cation Transporter
01
Overview
Organic Cation Transporter 2 (OCT2), encoded by the SLC22A2 gene, is a polyspecific transporter primarily expressed in the kidney. It mediates the uptake of a wide range of organic cations, including drugs, toxins, and metabolites, across the cell membrane via facilitated diffusion. OCT2 plays a crucial role in renal drug handling and is a major determinant of pharmacokinetics for many drugs. Its broad substrate specificity leads to clinically relevant drug-drug interactions. Emerging evidence suggests potential roles in other tissues, such as the pancreas.
- Other names
- SLC22A2
02
Mechanism of action
Inhibition of organic cation transport
03
Biological functions
Transmembrane transportFacilitated diffusionDrug transportMetabolite transport
04
Disease associations
Drug-drug interactionsNephrotoxicity
05
Safety considerations
Drug-drug interactions altering drug efficacy or safety profilesCellular toxicity due to transport of nephrotoxic compounds
06
Interacting drugs
Metformin
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