Organic cation transporter type 2 (OCT2)

Organic cation transporter type 2 (OCT2, SLC22A2) is a polyspecific membrane transporter primarily expressed in the basolateral membrane of renal proximal tubules. It facilitates the renal secretion and clearance of a broad range of endogenous and exogenous organic cations, including many drugs such as metformin and platinum-based chemotherapeutics. OCT2 contains 12 transmembrane domains and functions as part of the solute carrier family, contributing to drug pharmacokinetics and susceptibility to drug interactions. Genetic polymorphisms in SLC22A2 can significantly affect drug distribution, efficacy, and toxicity[2][3][4][5][6]. OCT2 expression is also documented in the pancreas, particularly in β cells, with evidence supporting regulation by glucose and possible functional interaction with the glucose transporter GLUT2[4][6]. OCT2 plays a major role in kidney drug elimination, and its inhibition or genetic variance can result in clinically relevant changes in drug handling and safety[3][4][5].

Other names

SLC22A2renal organic cation transporter 2OCT2solute carrier family 22 member 2

Facilitated diffusion: transport of organic cations down their electrochemical gradient; Drug uptake into cells via transporter-mediated process; Competition and inhibition by co-administered substances