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Organic Thiophosphates
- Molecular classification
- Organophosphorus compounds, Esters, Thioesters
01
Overview
Organic thiophosphates are a class of organophosphorus compounds characterized by the replacement of one or more oxygen atoms in the phosphate group with sulfur. They have various applications as pesticides, chemotherapy adjuvants, and in antisense oligonucleotide therapeutics. Their biological activity often stems from cholinesterase inhibition. Metabolism primarily involves oxidation, hydrolysis, and glutathione conjugation.
- Other names
- OrganothiophosphatesPhosphorothioates
02
Mechanism of action
Cholinesterase inhibition leading to acetylcholine accumulation at synapses (for pesticides). Phosphorothioate oligonucleotides interact with mRNA.
03
Biological functions
Cholinesterase inhibition (for pesticide activity)Antisense oligonucleotide therapeuticsChemotherapy adjuvant
04
Disease associations
Pesticide poisoningCancer (potential protective role)Neurological effects (chronic exposure)
05
Safety considerations
Acute neurotoxicity due to cholinesterase inhibitionChronic neurological effectsSperm chromatin condensation alterations
06
Interacting drugs
Malathion
2 more in the full profile.
07
Biomarkers
Diethylthiophosphate (DETP) as a biomarker of exposure
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