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Target intelligence / Profile preview
Organophosphorus hydrolase (OPH)
- Target
- OPH
- Molecular classification
- Enzyme, Hydrolase, Amidohydrolase superfamily
01
Overview
Organophosphorus hydrolase (OPH), also known as phosphotriesterase (PTE), is a zinc-dependent enzyme found principally in soil bacteria such as Brevundimonas diminuta and Flavobacterium species. It belongs to the amidohydrolase superfamily and catalyzes the hydrolysis of a wide range of organophosphorus compounds, including many pesticides and chemical warfare agents. OPH has been engineered and explored as a therapeutic agent to detoxify organophosphate poisoning and is used in bioremediation applications for environmental clean-up. Structural and mechanistic studies reveal an (α/β)₈-barrel fold and a binuclear metal center essential for catalysis.
- Other names
- PhosphotriesteraseAryldialkylphosphatasePTE
02
Mechanism of action
Enzymatic hydrolysis of organophosphorus esters, breaking down highly toxic OP pesticides and nerve agents into non-toxic products
03
Biological functions
Detoxification of organophosphorus pesticides and nerve agentsBioremediationEnvironmental decontaminationProtection against OP poisoning
04
Disease associations
Poisoning (protection/therapeutic agent for organophosphate pesticide or nerve agent toxicity)Other (bioremediation applications)
05
Safety considerations
Immunogenicity and delivery of biologic enzyme as a drugPotential instability in vivo
06
Interacting drugs
None with OPH directly approved, but it is explored as a therapeutic biologic
07
Biomarkers
None commonly used for patient selection; research uses OPH activity or OP levels in biological samples for monitoring
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