Origin recognition complex subunit 2 (ORC2)

Origin recognition complex subunit 2 (ORC2) is one of the six subunits of the highly conserved origin recognition complex (ORC), which is essential for the initiation of DNA replication in eukaryotes. ORC2 helps ORC bind to replication origins in an ATP-dependent manner and serves as a platform for the assembly of additional initiation factors such as Cdc6 and the MCM helicase complex[1][3][5]. ORC2 is also implicated in non-replicative functions, including heterochromatin formation, maintenance of centromeric histone methylation, chromosome segregation, centrosome duplication, and mRNA nuclear export[5]. Mutations in ORC2 can cause microcephalic primordial dwarfism (Meier-Gorlin syndrome) and are associated with certain immunodeficiency syndromes[2][3]. Currently, ORC2 itself is not targeted by approved or experimental drugs and is not considered a drug target or receptor, although disruption can affect pathways commonly altered in cancer and developmental disease[3][5].

Other names

ORC2Lorigin recognition complex protein 2 homologorigin recognition complex, subunit 2 homolog