Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Origin recognition complex subunit 4 (ORC4)
- Target
- ORC4
- Molecular classification
- Other (subunit of the origin recognition complex), ATPase-containing protein (AAA+ ATPase family)
01
Overview
Origin recognition complex subunit 4 (ORC4) is a protein that forms part of the six-subunit origin recognition complex (ORC), which is essential for the initiation of DNA replication in eukaryotic cells.[1][3][5][6][7][8] ORC4, along with the other five ORC subunits (ORC1-6), binds to specific DNA sequences at origins of replication, serving as a critical platform for recruitment of additional factors (such as CDC6, MCM2-7, and CDT1) that assemble the pre-replicative complex, allowing DNA synthesis to begin.[5][6][7][8] ORC4 contains an ATPase domain (AAA+ ATPase), and its ATP-binding motifs are crucial for replication activity. Mutations in ORC4 can disrupt replication licensing and are implicated in rare genetic diseases such as Meier-Gorlin syndrome, characterized by growth and developmental defects.[3][5][8] ORC4 does not currently represent a druggable therapeutic target, and no approved drugs directly interact with this protein.
- Other names
- ORC4LHsORC4Orc4pORC4Porigin recognition complex, subunit 4 homolog
02
Mechanism of action
Not applicable (no drugs directly targeting ORC4)
03
Biological functions
Initiation of DNA replicationPre-replicative complex assemblyChromosome maintenanceReplication licensing (ensuring DNA is duplicated only once per cell cycle)
04
Disease associations
Meier-Gorlin syndromeOther developmental disorders (e.g., microduplication syndromes)
05
Safety considerations
Loss or mutation impairs cell proliferation/division, may contribute to developmental syndromes
06
Interacting drugs
None known (no evidence of clinically approved drugs directly targeting ORC4)
07
Biomarkers
Mutations in ORC4 are biomarkers for Meier-Gorlin syndrome
Beyond the preview
Go deeper on Origin recognition complex subunit 4 (ORC4).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Origin recognition complex subunit 4 (ORC4).