Origin recognition complex subunit 6 (ORC6)

Origin recognition complex subunit 6 (ORC6) is the sixth and smallest subunit of the origin recognition complex (ORC), a highly conserved six-protein complex essential for the initiation of DNA replication in eukaryotic cells[2][3][4]. ORC6 is encoded by the *ORC6* gene (also called *ORC6L*) and plays a key DNA-binding role, anchoring the ORC to replication origins and facilitating pre-replication complex assembly[1][6]. Structurally, human ORC6 contains three independent domains and a distinct DNA-binding domain[4]. Functionally, ORC6 is essential for viability and proper chromosome replication and segregation; it also plays a role in cytokinesis, sometimes independently of the ORC[2][4][5]. In humans, mutations can result in syndromes characterized by developmental defects, including Meier-Gorlin syndrome[4]. ORC6 is not a typical therapeutic target, with no direct drugs acting upon it, but it is crucial for understanding DNA replication and cell division biology.

Other names

Origin recognition complex subunit 6ORC6ORC6Lorigin recognition complex protein 6

not a direct drug target; mechanism data associated with DNA binding and protein-protein interactions within the pre-replication complex