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Target intelligence / Profile preview
Ornithine Aminotransferase (OAT)
- Target
- OAT
- Molecular classification
- Enzyme, Aminotransferase
01
Overview
Ornithine aminotransferase (OAT) is a mitochondrial enzyme that catalyzes the reversible transfer of the δ-amino group from L-ornithine to α-ketoglutarate, producing glutamate-5-semialdehyde and glutamate. It plays a key role in the interconversion of ornithine, proline, and glutamate, linking the urea cycle with proline and glutamate metabolism. Deficiency leads to gyrate atrophy, a rare inherited disorder.
- Other names
- Ornithine δ-aminotransferase
02
Mechanism of action
Gabaculine: Inhibits OAT by covalently binding to the PLP cofactor site.
03
Biological functions
Amino acid metabolismUrea cycle regulationProline metabolismGlutamate metabolismRegulation of ornithine levels
04
Disease associations
Gyrate atrophy
05
Safety considerations
Inhibition may disrupt amino acid metabolism
06
Interacting drugs
Gabaculine
07
Biomarkers
Ornithine levels (in Gyrate atrophy)
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