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Ornithine Decarboxylase 1 (ODC1)
- Target
- ODC1
- Molecular classification
- Enzyme
01
Overview
Ornithine decarboxylase 1 (ODC1) is a gene encoding the enzyme ornithine decarboxylase, which catalyzes the decarboxylation of ornithine to putrescine, the first and rate-limiting step in polyamine biosynthesis. Polyamines are essential for cell growth and proliferation. ODC1 is notable for its regulation by antizyme and ubiquitin-independent proteasomal degradation. Dysregulation of ODC/ODC1 has been linked with various cancers and neurodevelopmental disorders. The enzyme's activity can be specifically inhibited by compounds such as DL-alpha-difluoromethylornithine (DFMO), which has been used experimentally both as an anti-cancer agent and as a tool for studying developmental biology.
- Other names
- ODCOrnithine Decarboxylase
02
Mechanism of action
Inhibition of ornithine decarboxylase activity
03
Biological functions
Cell growthCell proliferationDNA stabilizationDNA repairPolyamine biosynthesis
04
Disease associations
CancerNeurodevelopmental disorders
05
Interacting drugs
DL-alpha-difluoromethylornithine (DFMO)
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