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Orthopoxvirus

Molecular classification: Virus, DNA Virus, Poxviridae, Chordopoxvirinae

Overview

Orthopoxvirus is a genus of large, enveloped, double-stranded DNA viruses within the family Poxviridae. These viruses are zoonotic, infecting a range of mammals (including humans) and some arthropods. Notable human pathogens in this genus include variola virus (smallpox), monkeypox virus (mpox), cowpox virus, and vaccinia virus. Potential antiviral targets focus on viral proteins essential for entry/fusion (glycoproteins mediating attachment/fusion), enzymes involved in early transcription/replication steps encoded by conserved genes within the central genome region.

Biological functions

Viral replicationHost cell entryImmune evasion

Disease associations

InfectionSmallpoxMpoxCowpoxVaccinia

Safety considerations

Drug resistanceOff-target effectsImmune-related adverse events

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