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Target intelligence / Profile preview
Orthopoxvirus DNA Polymerase (OPV Pol)
- Target
- OPV Pol
- Molecular classification
- Enzyme, DNA-dependent DNA polymerase, B-family DNA polymerase, Uracil-DNA glycosylase
01
Overview
Orthopoxvirus DNA polymerase is an essential multi-subunit enzyme complex required for faithful viral genome duplication and repair. Its unique assembly—including both canonical B-family features and specialized cofactors—enables efficient cytoplasmic replication while providing multiple points amenable to therapeutic intervention against poxviral diseases such as smallpox or mpox/monkeypox.
- Other names
- MPXV DNA PolymeraseVaccinia Virus DNA PolymeraseF8-A22-E4 complex (MPXV)E9-A20-D4 complex (Vaccinia)
02
Mechanism of action
Inhibition of viral DNA synthesis
03
Biological functions
Genome replicationDNA synthesisProofreadingBase excision repairViral propagation
04
Disease associations
Smallpox (Variola virus infection)Monkeypox (MPXV infection)CowpoxOrthopoxvirus infections
05
Safety considerations
Potential for resistance developmentOff-target effects on host cell polymerases (though less likely due to structural differences)
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