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Target intelligence / Profile preview
Orthopoxvirus Phospholipase F13 (F13)
- Target
- F13
- Molecular classification
- Enzyme, Phospholipase, Phospholipase D superfamily
01
Overview
Orthopoxvirus Phospholipase F13 is a highly conserved viral protein essential for the formation of the wrapped form of the virus, which is required for efficient cell-to-cell spread and production of extracellular virions. It possesses broad-specificity lipase activity and is a major envelope protein. F13 is a target for antiviral drugs like Tecovirimat.
- Other names
- F13L proteinVACV F13MPXV F13VARV F13
02
Mechanism of action
Inhibition of F13 function, blocking interaction with other envelope proteins (e.g., B5), thereby preventing efficient formation/release of infectious extracellular particles.
03
Biological functions
Viral assemblyViral egressCell-to-cell spreadLipase activityMembrane biogenesis
04
Disease associations
InfectionOrthopoxvirus infectionVaccinia virus infectionMonkeypox virus infectionVariola virus (Smallpox) infection
05
Safety considerations
Potential for drug resistanceOff-target effects of inhibitors
06
Interacting drugs
Tecovirimat (ST-246/Arestvyr)
1 more in the full profile.
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