Orthosilicic acid (OSA)

Orthosilicic acid (OSA) is the primary bioavailable form of silicon in the human body, existing as a small, uncharged molecule (H4SiO4) that is readily absorbed by the gastrointestinal tract (PubChem CID 14942). Although it is not a traditional therapeutic target like a receptor or enzyme, it is a critical bioactive molecule essential for the structural integrity and development of connective tissues, including bone, skin, hair, and nails (Jugdaohsingh, 2007). OSA has been shown to stimulate the synthesis of Type I collagen and promote the differentiation of osteoblasts, which are vital processes for maintaining bone mineral density and skeletal health (Reffitt et al., 2003). Furthermore, OSA plays a significant role in aluminum detoxification by forming insoluble hydroxyaluminosilicates, thereby reducing the systemic absorption and neurotoxicity of aluminum (Exley, 2013). Clinical studies have demonstrated that stabilized forms of OSA, such as choline-stabilized orthosilicic acid, can improve skin elasticity and reduce hair and nail brittleness (Barel et al., 2005). Consequently, it is widely utilized in nutritional pharmacology for its osteogenic and dermatological benefits.

Other names

Monosilicic acidSilicic acidSilicon hydroxideH4SiO4

Orthosilicic acid acts as a biological source of silicon, which serves as a cofactor for prolyl hydroxylase enzymes to promote collagen cross-linking and facilitates the mineralization of the bone matrix while also chelating aluminum to reduce its toxicity.