OS9 endoplasmic reticulum lectin (OS9)

OS9 endoplasmic reticulum lectin (OS9) is a human protein encoded by the OS9 gene and is highly expressed in certain cancers, including osteosarcoma[1]. OS9 functions as a lectin within the endoplasmic reticulum, where it is a component of the HRD1 complex involved in ER-associated degradation (ERAD), a process essential for cellular quality control by recognizing and promoting the removal of misfolded glycoproteins[2][5][6]. It binds to specific protein substrates, including the calcium-sensing receptor and hypoxia-inducible factor 1 (HIF-1), thereby influencing protein turnover and cell signaling through ubiquitination and degradation[1][3][4]. OS9 serves as a key node in protein retention, folding surveillance, and the regulated removal of defective glycoproteins in the secretory pathway[2][5][6]. Although OS9's implication in osteosarcoma and protein misfolding suggests disease relevance, there are currently no approved drugs directly targeting OS9 nor established diagnostic biomarkers[1].

Other names

Protein OS-9ERLEC2Amplified in osteosarcoma 9Endoplasmic reticulum lectin 2Erlectin 2Osteosarcoma amplified 9Endoplasmic reticulum associated proteinOS-9