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Osteoconduction via scaffold provision describes the process whereby a three-dimensional scaffold allows the ingrowth of cells, blood vessels, and new bone tissue from the host into the implanted material, facilitating the physical bridging and healing of a bone defect[1][2][3]. This process depends heavily on scaffold properties (such as porosity, surface structure, and material composition)[2][3][4]. Osteoconductive scaffolds do not inherently induce bone formation, but they provide the structural template within which bone regeneration can occur[1][2][3][4][5]. Common materials include hydroxyapatite, tricalcium phosphate, ceramics, polymers, and composites[2][3][5]. This is not a specific protein, receptor, or gene, but rather a general feature or property of biomaterial implants in orthopedic and reconstructive surgery.
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