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Osteopontin (None)
- Target
- None
- Molecular classification
- Extracellular matrix protein, Cytokine, Phosphoprotein, Glycoprotein
01
Overview
Osteopontin (OPN) is a multifunctional, extracellular structural protein involved in bone remodeling, immune regulation, and various disease processes, including cancer and inflammation. It interacts with integrins and CD44 receptors, mediating cell adhesion, migration, and signaling.
- Other names
- Bone sialoprotein IBSP-1BNSPEarly T-lymphocyte activation 1ETA-1Secreted phosphoprotein 1SPP1NephropontinUropontinUrinary stone protein
02
Mechanism of action
Blocking OPN interactions with integrins or CD44; inhibition of OPN expression; targeting downstream signaling pathways activated by OPN.
03
Biological functions
Cell adhesionCell migrationCell signalingBone remodelingImmune regulationInflammationWound healing
04
Disease associations
CancerRheumatoid arthritisCardiovascular diseaseAtherosclerosisMultiple sclerosisFibrosisKidney stones
05
Safety considerations
Potential for off-target effects due to widespread expressionComplexity of OPN signaling pathways makes targeted therapies challengingModulation of immune responses can have unintended consequences
06
Biomarkers
Cancer diagnosis and prognosisMonitoring inflammationAssessing bone turnover
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