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Target intelligence / Profile preview
Osteoprotegerin (OPG)
- Target
- OPG
- Molecular classification
- Secreted glycoprotein, Tumor necrosis factor receptor superfamily, Receptor
01
Overview
Osteoprotegerin (OPG) is a secreted glycoprotein and a member of the tumor necrosis factor receptor superfamily that acts as a soluble decoy receptor for RANKL. By sequestering RANKL, OPG prevents RANKL from binding to RANK on osteoclast precursors and mature osteoclasts, thus inhibiting osteoclast differentiation, activation, and survival. OPG plays a central role in bone metabolism by regulating the balance between bone resorption and formation, making it a key therapeutic target for osteoporosis and other bone disorders.
- Other names
- Osteoclastogenesis inhibitory factorOCIF
02
Mechanism of action
Binds to RANKL, preventing its interaction with RANK on osteoclast precursors and mature osteoclasts, thereby inhibiting osteoclast differentiation, activation, and survival.
03
Biological functions
Inhibition of osteoclastogenesisSuppression of bone resorptionRegulation of bone metabolismDecoy receptor for RANKLModulation of apoptosis
04
Disease associations
OsteoporosisOsteopetrosisMetabolic bone lossInflammatory bone loss
05
Interacting drugs
Recombinant OPG
1 more in the full profile.
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