Other blood plasma proteins

Other blood plasma proteins is a heterogeneous category representing the diverse set of proteins found in the liquid portion of blood, excluding specific clotting factors or enzymes often listed separately. This group primarily includes albumin, the most abundant plasma protein, which maintains oncotic pressure and acts as a carrier for various ligands (StatPearls: Physiology, Albumin). It also encompasses globulins and other transport proteins that facilitate the movement of lipids, hormones, and metal ions throughout the circulatory system (NCBI: Plasma Proteins). While these proteins are essential for maintaining physiological homeostasis, they are generally not considered primary therapeutic targets; instead, they are critical determinants of drug pharmacokinetics (PubMed: Drug-Plasma Protein Binding). Many drugs, such as warfarin and certain NSAIDs, bind extensively to these proteins, which limits the free fraction of the drug available to reach its intended site of action. Consequently, variations in the concentration of these proteins due to liver or kidney disease can significantly alter drug efficacy and safety profiles.

Other names

Plasma proteinsSerum proteinsCirculating proteinsBlood proteins

Non-specific protein binding and transport