Other kinases

The designation 'Other kinases' is a non-specific categorical term used to group various kinases that are not classified within the major, well-defined kinase families such as Tyrosine Kinases (TK), TKL (Tyrosine Kinase-Like), or CMGC (CDK, MAPK, GSK3, CLK) (Manning et al., 2002, Science). This group includes a diverse array of enzymes that catalyze the transfer of phosphate groups to proteins, lipids, or other molecules, thereby regulating critical cellular processes including signal transduction, metabolism, and gene expression (UniProt, 2024). Because this is a catch-all classification rather than a specific molecular entity, it encompasses a wide range of potential therapeutic targets involved in diseases like cancer and inflammation (ChEMBL Database). Drugs interacting with members of this group typically act as competitive inhibitors of the ATP-binding site to prevent substrate phosphorylation. However, the lack of specificity in the term makes it unsuitable for precise drug-target annotation in a clinical or biochemical context. It is often used in high-throughput screening or database organization to account for kinases with unique structural or functional features that defy standard categorization. Consequently, the term lacks the specificity required for targeted therapy development or clinical biomarker identification.

Other names

Miscellaneous kinasesAtypical kinasesNon-canonical kinasesKinase group 'Other'

Inhibition of phosphotransferase activity by competing with ATP binding or substrate recognition.