Other oncogenic pathway mRNAs with miR-193a-3p recognition sites

The term Other oncogenic pathway mRNAs with miR-193a-3p recognition sites refers to a heterogeneous group of messenger RNAs (mRNAs) that are post-transcriptionally regulated by the tumor-suppressive microRNA miR-193a-3p. This microRNA exerts its biological effect by binding to specific seed-match sequences, typically within the 3' untranslated regions (UTRs) of target mRNAs, resulting in mRNA cleavage or translational repression (Yu et al., 2015, PubMed: 25670458). Prominent targets within this group include well-characterized oncogenes such as ERBB4, KRAS, CCND1, and MCL1, which are central to the MAPK/ERK and PI3K/Akt signaling pathways (Li et al., 2016, PubMed: 26918254; Chen et al., 2014, PubMed: 24441033). In many human malignancies, miR-193a-3p is frequently downregulated, leading to the pathological overexpression of these oncogenic mRNAs and driving tumor progression, survival, and metastasis. Therapeutic strategies often focus on the use of miR-193a-3p mimics to restore this natural regulatory network and simultaneously silence multiple oncogenic drivers. However, the clinical development of such therapies is complicated by the potential for off-target effects and the requirement for sophisticated delivery systems to reach target tissues effectively.

Other names

miR-193a-3p target genesmiR-193a-3p regulated mRNAsMicroRNA-193a-3p targets

RNA interference-mediated gene silencing via translational repression and mRNA degradation