Other Pseudomonas aeruginosa surface receptors

The category Other Pseudomonas aeruginosa surface receptors encompasses a diverse array of proteins and molecular structures located on the outer membrane of the Gram-negative bacterium Pseudomonas aeruginosa (UniProt, 2024). This group includes critical virulence factors such as the Type III secretion system (T3SS) tip protein PcrV, which facilitates the delivery of toxins into host cells, and outer membrane porins like OprF that mediate adhesion and structural stability (PubMed: 25391483). These surface components are vital for the pathogen's ability to colonize host tissues, evade immune responses, and survive in hostile environments like the cystic fibrosis lung (NIH: PMC3133110). As they are exposed to the extracellular space, these receptors are primary targets for the development of monoclonal antibodies and vaccines aimed at neutralizing bacterial toxicity or enhancing immune clearance (PubMed: 19752311). However, the high degree of genetic diversity among P. aeruginosa strains and the protective nature of biofilms present significant hurdles to the broad clinical success of therapies targeting these surface receptors.

Other names

Pseudomonas aeruginosa surface proteinsP. aeruginosa outer membrane receptorsPseudomonas cell surface antigens

Neutralization of the Type III secretion system, inhibition of bacterial attachment to host epithelia, and promotion of antibody-dependent opsonophagocytosis (PubMed: 25391483, NIH: PMC3133110).